Synthesis and cytotoxic evaluation of hydroxycinnamic acid rhodamine B conjugates
نویسندگان
چکیده
منابع مشابه
Synthesis and cytotoxic evaluation of several oleanolic acid–uracil/thymine conjugates†‡
A total of 16 targeted oleanolic acid–uracil/thymine hybrids were designed and synthesized as potential cytotoxic agents. Most IC50 values were under 10.0 μM, with some of them under 0.1 μM in vitro test against tested cells (Hep-G2, A549, BGC-823, MCF-7 and PC-3). These hybrids displayed much more potent inhibitory activities compared with oleanolic acid and commercial anticancer drug 5-fluoro...
متن کاملSynthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents
In order to develop agents with superior chemopreventive and chemotherapeutic properties against hepatocellular carcinomas, mitochondria-targeted hydroxycinnamic acids (MitoHCAs) were synthesized by conjugation with a triphenylphosphonium cation. These synthetic compounds were evaluated for their antioxidant activities in hepatic mitochondria, including against OH∙- and ROO∙- induced lipid pero...
متن کاملProduction of hydroxycinnamoyl-shikimates and chlorogenic acid in Escherichia coli: production of hydroxycinnamic acid conjugates
BACKGROUND Hydroxycinnamates (HCs) are mainly produced in plants. Caffeic acid (CA), p-coumaric acid (PA), ferulic acid (FA) and sinapic acid (SA) are members of the HC family. The consumption of HC by human might prevent cardiovascular disease and some types of cancer. The solubility of HCs is increased through thioester conjugation to various compounds such as quinic acid, shikimic acid, mali...
متن کاملhistological evaluation of the effect of three medicaments; trichloracetic acid, formocresol and mineral trioxide aggregate on pulpotomized teeth of dogs
چکیده ندارد.
15 صفحه اولSynthesis and Cytotoxic Evaluation of Fatty Acid Based- Amino Alcohols
In the present investigation, we describe the synthesis of β-amino alcohols from a medium chain fatty acid, 10-undecenoic acid and evaluation of their cytotoxicity. Nucleophilic ring opening reactions of epoxy undecanoates of varying ester chain lengths (C1-C8) with aniline in equimolar ratio (1:1) was carried out using Bronsted acidic ionic liquid, 1methylimidazolium tetrafluoroborate, thus pl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Results in Chemistry
سال: 2020
ISSN: 2211-7156
DOI: 10.1016/j.rechem.2020.100057